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Hepatitis C


Hepatitis C is a virus that can infect the liver. If left untreated, it can sometimes cause serious and potentially life-threatening damage to the liver over many years.

However, with modern treatments it's often possible to cure the infection and most people with it will have a normal life expectancy.

It's estimated that around 215,000 people in the UK have hepatitis C.

You can become infected with it if you come into contact with the blood of an infected person.

Symptoms of hepatitis C

Hepatitis C often doesn't have any noticeable symptoms until the liver has been significantly damaged. This means many people have the infection without realising it.

When symptoms do occur, they can be mistaken for another condition. Symptoms can include:

  • flu-like symptoms, such as muscle aches and a high temperature (fever)
  • feeling tired all the time
  • loss of appetite
  • abdominal (tummy) pain
  • feeling and being sick

The only way to know for certain if these symptoms are caused by hepatitis C is to get tested (see below).

How do you get hepatitis C?

The hepatitis C virus is usually spread through blood-to-blood contact.

Some ways the infection can be spread include:

  • sharing unsterilised needles – particularly needles used to inject recreational drugs
  • sharing razors or toothbrushes
  • from a pregnant woman to her unborn baby
  • through unprotected sex – although this is very rare

In the UK, most hepatitis C infections occur in people who inject drugs or have injected them in the past. It's estimated that around half of those who inject drugs have the infection.

Getting tested for hepatitis C

Seek medical advice if you have persistent symptoms of hepatitis C, or there's a risk you're infected, even if you don't have any symptoms. A blood test can be carried out to see if you have the infection.

Your GP, sexual health clinic, GUM (genitourinary medicine) clinic or drug treatment service all offer testing for hepatitis C.

Early diagnosis and treatment can help prevent or limit any damage to your liver and help ensure the infection isn't passed on to other people.

Treatments for hepatitis C

Hepatitis C can be treated with a combination of medicines that stop the virus multiplying inside the body. These usually need to be taken for several months.

Most people will take two main medications called pegylated interferon (a weekly injection) and ribavirin (a capsule or tablet), although newer tablet-only treatments are likely to replace the interferon injections for most people in the near future.

These newer hepatitis C medications have been found to make treatment more effective. They include simeprevir, sofosbuvir and daclatasvir.

Using the latest medications, up to 90% or more of people with hepatitis C may be cured. However, it's important to be aware that you won't be immune to the infection and should take steps to reduce your risk of becoming infected again (see below).

Complications of hepatitis C

If the infection is left untreated for many years, some people with hepatitis C will develop scarring of the liver (cirrhosis). Over time, this can cause the liver to stop working properly.

In severe cases, life-threatening problems such as liver failure (where the liver loses most or all of its functions) or liver cancer can eventually develop.

Treating hepatitis C as early as possible can help reduce the risk of these problems occurring.

Preventing hepatitis C

There's no vaccine for hepatitis C, but there are ways to reduce your risk of becoming infected, such as:

  • not sharing any drug-injecting equipment with other people – including needles and other equipment such as syringes, spoons and filters
  • not sharing razors or toothbrushes that might be contaminated with blood

The risk of getting hepatitis C through sex is very low. However, it may be higher if blood is present, such as menstrual blood or from minor bleeding during anal sex.

Condoms aren't usually necessary to prevent hepatitis C for long-term heterosexual couples, but it's a good idea to use them when having anal sex or sex with a new partner.

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Many people with hepatitis C don't have any symptoms and are unaware they have the infection. They may develop symptoms later on as their liver becomes increasingly damaged.

Early symptoms

Only around one in every three or four people will have any symptoms during the first six months of a hepatitis C infection. This stage is known as acute hepatitis C.

If symptoms do develop, they usually occur a few weeks after infection. Symptoms may include:

  • a high temperature of 38C (100.4F) or above
  • tiredness
  • loss of appetite
  • abdominal (tummy) pains
  • feeling and being sick

Around one in every five people who experiences symptoms will also have yellowing of the eyes and skin. This is known as jaundice.

In around one in every four people infected with hepatitis C, the immune system will kill the virus within a few months and the person will have no further symptoms, unless they become infected again.

In the remaining cases, the virus persists inside the body for many years. This is known as chronic hepatitis.

Later symptoms

The symptoms of long-term (chronic) hepatitis C can vary widely. In some people, symptoms may be barely noticeable. In others, they can have a significant impact on quality of life.

The symptoms can also go away for long periods of time and then return.

Some of the most common problems experienced by people with chronic hepatitis C include:

  • feeling tired all the time
  • joint and muscle aches and pain
  • feeling sick
  • problems with short-term memory, concentration and completing complex mental tasks such as mental arithmetic – many people describe this as "brain fog"
  • mood swings
  • depression or anxiety
  • indigestion or bloating
  • itchy skin
  • abdominal pain

If left untreated, the infection can eventually cause the liver to become scarred (cirrhosis). Signs of cirrhosis can include jaundice, vomiting blood, dark stools and a build-up of fluid in the legs or abdomen.

When to seek medical advice

See your GP if you persistently have any of the later symptoms above, or if they keep returning. They may recommend having a blood test that can check for hepatitis C.

None of the symptoms above mean you definitely have hepatitis C, but it's important to get them checked out.

You should also speak to your GP about getting tested if there's a risk you're infected, even if you don't have any symptoms. This particularly includes people who inject drugs or have done so in the past.


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You can become infected with hepatitis C if you come into contact with the blood of an infected person.

Other bodily fluids can also contain the virus, but blood contains the highest level of it. Just a small trace of blood can cause an infection. At room temperature, it's thought the virus may be able survive outside the body in patches of dried blood on surfaces for up to several weeks.

The main ways you can become infected with the hepatitis C virus are described below.

Injecting drugs

People who inject drugs, including illegal recreational drugs and performance-enhancing drugs such as anabolic steroids, are at the highest risk of becoming infected with hepatitis C.

Almost 90% of hepatitis C cases in the UK occur in people who inject drugs or have injected them in the past. It's estimated that around half of the people in the UK who inject drugs have the infection.

The infection can be spread by sharing needles and associated equipment. Injecting yourself with just one contaminated needle may be enough to become infected.

It's also possible to get the infection by sharing other equipment used to prepare or take drugs – such as spoons, filters, pipes and straws – that have been contaminated with infected blood.

Less common causes

Unprotected sex

Hepatitis C may be transmitted during unprotected sex (sex without using a condom), although this risk is considered very low.

The risk of transmission through sex may be higher among men who have sex with men. The risk is also increased if there are genital sores or ulcers from a sexually transmitted infection, or if either person also has HIV.

The best way to prevent transmission of hepatitis C through sex is to use a male condom or female condom. However, as the risk is very low for couples in a long-term relationship, many choose not to use a condom.

If your partner has hepatitis C, you should be tested for the condition.

Blood donations before September 1991

Since September 1991, all blood donated in the UK is checked for the hepatitis C virus. If you received blood transfusions or blood products before this date, there's a small possibility you may have been infected with hepatitis C.

Blood transfusions and treatment abroad

If you have a blood transfusion or medical or dental treatment overseas where medical equipment is not sterilised properly, you may become infected with hepatitis C. The virus can survive in traces of blood left on equipment.

Sharing toothbrushes, scissors and razors

There's a potential risk that hepatitis C may be passed on through sharing items such as toothbrushes, razors and scissors, as they can become contaminated with infected blood.

Equipment used by hairdressers, such as scissors and clippers, can pose a risk if it has been contaminated with infected blood and not been sterilised or cleaned between customers. However, most salons operate to high standards, so this risk is low.

Tattooing and body piercing

There is a risk that hepatitis C may be passed on through using tattooing or body piercing equipment that has not been properly sterilised. However, most tattoo and body piercing parlours in the UK operate to high standards and are regulated by law, so this risk is low.

Mother to child

There is a small chance that a mother who is infected with the hepatitis C virus will pass the infection on to her baby. This happens in around 5% of cases.

It's not thought that the virus can be passed on by a mother to her baby in her breast milk.

Needlestick injury

There's a small (approximately one in 30) risk of getting hepatitis C if your skin is accidentally punctured by a needle used by someone with hepatitis C.

Healthcare workers, nurses and laboratory technicians are at increased risk because they are in regular close contact with blood and bodily fluids that may contain blood.

Hepatitis C myths

The hepatitis C virus isn't spread through social contact, such as hugging, kissing and sharing kitchen utensils.

It can't be passed on through toilet seats.

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If you think you may have been exposed to hepatitis C, taking a test will put your mind at rest or, if the test is positive, allow you to start treatment early.

GP surgeries, sexual health clinics, GUM (genitourinary medicine) clinics or drug treatment services all offer testing for hepatitis C.

Who should get tested?

You should consider getting tested for hepatitis C if you're worried you could have been infected or you fall into one of the groups at an increased risk of being infected.

Hepatitis C often has no symptoms, so you may still be infected if you feel healthy.

The following groups of people are at an increased risk of hepatitis C:

  • ex-drug users and current drug users, particularly users of injected drugs
  • people who received blood transfusions before September 1991
  • recipients of organ or tissue transplants before 1992
  • people who have lived or had medical treatment in an area where hepatitis C is common – high risk areas include North Africa, the Middle East and Central and East Asia
  • babies and children whose mothers have hepatitis C
  • anyone accidentally exposed to the virus, such as health workers
  • people who have received a tattoo or piercing where equipment may not have been properly sterilised
  • sexual partners of people with hepatitis C

If you continue to engage in high-risk activities, such as injecting drugs frequently, regular testing may be recommended. Your doctor will be able to advise you about this.

Testing for hepatitis C

Hepatitis C is diagnosed using two blood tests: the antibody test and the PCR test. The results usually come back within two weeks.

The antibody test

The antibody blood test determines whether you have ever been exposed to the hepatitis C virus by testing for the presence of antibodies to the virus. Antibodies are produced by your immune system to fight germs.

The test will not show a positive reaction for some months after infection because your body takes time to make these antibodies.

If the test is negative, but you have symptoms or you may have been exposed to hepatitis C, you may be advised to have the test again.

A positive test indicates that you have been infected at some stage. It doesn't necessarily mean you are currently infected, as you may have since cleared the virus from your body.

The only way to tell if you are currently infected is to have a second blood test, called a PCR test.

The PCR test

The PCR blood test checks if the virus is still present by detecting whether it is reproducing inside your body.

A positive test means that your body has not fought off the virus, and the infection has progressed to a chronic (long-term) stage.

Further tests

If you have an active hepatitis C infection, you will be referred to a specialist for further tests to check if your liver has been damaged.

The tests you may have include:

  • blood tests – these measure certain enzymes and proteins in your bloodstream that indicate whether your liver is damaged or inflamed
  • ultrasound scans – where sound waves are used to test how stiff your liver is (stiffness suggests the liver is scarred)

The specialist can also talk to you about any treatment you may need.

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Hepatitis C can often be treated successfully by taking a combination of medicines for several months.

If the infection is diagnosed in the early stages, known as acute hepatitis, treatment may not need to begin straight away. Instead, you may have another blood test after a few months to see if your body fights off the virus.

If the infection continues for several months, known as chronic hepatitis, treatment will usually be recommended.

Your treatment plan

Treatment for hepatitis C involves:

  • making lifestyle changes to help prevent further damage to your liver and reduce the risk of spreading the infection
  • taking a combination of two or three medications to fight the virus – this is known as combination therapy

You'll normally need to take medication for 12 to 48 weeks. This length of time will depend on the exact medicines you're taking and which version (strain) of the hepatitis C virus you have. Your doctor will advise you about this.

There are six main strains of the virus. In the UK, the most common strains are known as "genotype 1" and "genotype 3".

During treatment, you should have blood tests to check if your medication is working. If the test shows treatment is having little effect, it may be stopped as further treatment may be of little use.

Lifestyle measures

There are some things you can do to help limit any damage to your liver and prevent the infection spreading to others. These can include:

  • eating a healthy and balanced diet
  • exercising regularly
  • cutting out alcohol or limiting your intake
  • stopping smoking
  • keeping personal items, such as toothbrushes or razors, for your own use
  • not sharing any needles or syringes with others

Hepatitis C medications

Currently, treatment for chronic hepatitis C usually involves taking two main medicines:

  • pegylated interferon – a medication that encourages the immune system to attack the virus
  • ribavirin – an antiviral medication that stops the virus reproducing

These medications may just be taken together, although they're often combined with a third medication, such as simeprevir or sofosbuvir.

These are newer hepatitis C medications that have been shown to make treatment more effective. Read more about all these medications below.

Pegylated interferon and ribavirin

Pegylated interferon is usually taken as a weekly injection. You can be trained to inject yourself at home. It usually needs to be taken for up to 48 weeks, depending on your circumstances.

Ribavirin is available as capsules, tablets or an oral solution. It's normally taken twice a day with food. It needs to be taken alongside pegylated interferon for up to 48 weeks.

For more information see the National Institute for Health and Care Excellence (NICE) guidelines on peginterferon alfa and ribavirin for the treatment of chronic hepatitis C.

Simeprevir and sofosbuvir

Simeprevir and sofosbuvir are two of the newest hepatitis C medications recommended by NICE in 2015. They also work by stopping the hepatitis C virus from reproducing.

Simeprevir may be recommended if you have genotype 1 or genotype 4 hepatitis C. Sofosbuvir is usually given to people with genotype 1 hepatitis C, although it can be used to treat the other genotypes in some cases.

Both medications come as a tablet that's taken with food once a day. They're usually taken for either 12, 24 or 48 weeks, depending on your circumstances.

For more information see the NICE guidelines on simeprevir for treating genotypes 1 and 4 chronic hepatitis C and sofosbuvir for treating chronic hepatitis C.

Other medications

A number of other medications are also available to treat hepatitis C – such as daclatasvir, ombitasvir and paritaprevir – although these haven't yet been recommended by NICE.

You can read about the draft NICE recommendations on the treatment of hepatitis C with daclatasvir, ledipasvir, ombitasvir, paritaprevir, ritonavir and dasabuvir on the NICE website. These recommendations haven’t been finalised yet, but are unlikely to change.

Research into even more effective medications is ongoing.

How effective is treatment?

The effectiveness of treatment for hepatitis C can depend on the strain of the virus you have.

Genotype 1 used to be more challenging to treat and, until quite recently, less than half of people treated would be cured.

However, with the newer medications now available, the chances of a cure can be much higher. Combinations of tablets can now have a cure rate of more than 90%.

This is higher than the chances of curing most other hepatitis C genotypes.

Treatment for genotype 3 will usually involve the standard treatments of pegylated interferon and ribavirin. About 70-80% of those treated will be cured.

If the virus is successfully cleared with treatment, it's important to be aware that you're not immune to the infection. This means, for example, that you could become infected again if you continue to inject drugs after treatment.

If treatment doesn't work, it may be repeated, extended or tried using a different combination of medicines.

Side effects of treatment

Side effects of combination therapy involving interferon are quite common. The new tablet treatments have far fewer side effects and most people feel unaffected by them.

If your treatment involves interferon, side effects can include:

  • flu-like symptoms, such as a headache, fatigue (extreme tiredness) and a high temperature (fever)
  • a reduced number of red blood cells (anaemia), which can make you feel tired and out of breath
  • a rash
  • depression
  • itchy skin
  • feeling and being sick
  • constipation or diarrhoea
  • problems sleeping (insomnia)
  • loss of appetite and weight loss

Hepatitis C medications can have unpredictable reactions when taken with other medicines or remedies. Always check with your specialist, GP or pharmacist before taking other types of medication.

Any side effects may improve with time as your body gets used to the medications. Tell your care team if any side effect is becoming particularly troublesome.

Coping with side effects can be challenging, but you should continue to take your medication as instructed. Missing doses may reduce the chances of you being cured.

Treatment during pregnancy

The medications used to treat hepatitis C, particularly ribavirin, can be harmful to unborn babies and aren't normally used during pregnancy.

If you're pregnant when diagnosed with the infection, treatment will usually be delayed until you have given birth. Otherwise, you'll be advised to use contraception throughout your treatment and you may need to have regular pregnancy tests.

If you're a man taking ribavirin, you shouldn't have sex with a pregnant women unless you use a condom. If your partner isn't pregnant, you should ensure contraception is used during the course of your treatment and your partner may need to have regular pregnancy tests.

Deciding against treatment

Some people with chronic hepatitis C decide against treatment. This may be because they:

  • don't have any symptoms
  • are willing to live with the risk of cirrhosis at a later date
  • don't feel the potential benefits of treatment outweigh the side effects treatment can cause

Your care team can give you advice about this, but the final decision about treatment will be yours.

If you decide not to have treatment but then change your mind, you can ask to be treated at any point.

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If left untreated, hepatitis C can sometimes cause scarring of the liver (cirrhosis). This can develop up to 20 years or more after you first become infected.

A number of things can increase your risk of getting cirrhosis, including:

Overall, up to one in every three people infected with hepatitis C will develop cirrhosis within 20 to 30 years. Some of these will then go on to develop liver failure or liver cancer.


If you have cirrhosis, the scarred tissue in your liver gradually replaces healthy tissue and prevents the liver from working properly.

There are usually few symptoms in the early stages. But as your liver loses its ability to function properly, you may experience:

  • tiredness and weakness
  • loss of appetite
  • weight loss
  • feeling sick
  • very itchy skin
  • tenderness or pain in your tummy
  • tiny red lines (blood capillaries) on the skin
  • yellowing of the skin and whites of the eyes (jaundice)

Other than a liver transplant, there's no cure for cirrhosis. However, lifestyle measures and hepatitis C medications can help stop the condition getting worse.

Liver failure

In severe cases of cirrhosis, the liver loses most or all of its functions. This is known as liver failure or end stage liver disease.

Each year, around 1 in every 20 people with hepatitis-associated cirrhosis will develop liver failure.

Symptoms of liver failure include:

  • hair loss
  • build-up of fluid in the legs, ankles and feet (oedema)
  • build-up of fluid in your tummy (ascites)
  • dark urine
  • black, tarry stools or very pale stools
  • frequent nosebleeds and bleeding gums
  • a tendency to bruise easily
  • vomiting blood

It's usually possible to live with liver failure for several years by taking medication. However, a liver transplant is currently the only way to cure the condition.

Liver cancer

It's estimated that around 1 in every 20 people with hepatitis-associated cirrhosis will develop liver cancer each year.

Symptoms of liver cancer can include:

  • loss of appetite
  • unexplained weight loss
  • tiredness
  • feeling and being sick
  • pain or swelling in your tummy
  • jaundice

Unfortunately, it's not usually possible to cure liver cancer, especially in people with cirrhosis, although treatment can help control your symptoms and slow the spread of the cancer.

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General questions

Below are answers to some questions about living with hepatitis C, including questions about diet, the workplace, travelling and having a baby.

Could anything I do make hepatitis C worse?

Drinking alcohol can increase the damage to your liver. If you have hepatitis C, you should try to cut out alcohol or limit your intake. If you need advice about this, ask your doctor or contact an alcohol self-help organisation.

Read some tips for cutting down your alcohol consumption and find out where to get alcohol support.

If you're concerned that you're addicted to alcohol and are unable to stop drinking, contact your GP. Treatments are available to help you quit.

Is there anything else I can do to help myself?

As well as cutting out alcohol, it can help to:

This is because being overweight, smoking and having more than one type of hepatitis can increase the chances of your liver being damaged if you have hepatitis C.

Do I need a special diet?

You won't usually need to change to a special diet if you have hepatitis C, but you will need to make sure you have a generally healthy, balanced diet.

Your diet should include plenty of fruit and vegetables, starchy foods, fibre and protein. Cut down on fatty, fried and processed food. Read more about what a balanced diet means.

If your liver is badly damaged, however, your doctor may suggest limiting your intake of salt and protein to avoid putting too much strain on your liver. A hospital dietitian can advise you on what you can and cannot eat.

How can I avoid spreading the infection to others?

You can reduce the risk of passing hepatitis C on to other people by:

  • keeping personal items, such as toothbrushes or razors, for your own use
  • cleaning and covering any cuts or grazes with a waterproof dressing
  • cleaning any blood from surfaces with household bleach
  • not sharing needles or syringes with others
  • not donating blood

The risk of spreading hepatitis C through sex is low. However, the risk is increased if there is blood present, such as menstrual blood or during anal sex.

Condoms aren't usually necessary for long-term heterosexual couples, but it's a good idea to use them when having anal sex or sex with a new partner.

Do I have to tell my boss?

You don't have to tell your boss that you have hepatitis C, unless you're a healthcare worker.

However, if hepatitis C is affecting your performance at work and your employer knows about your condition, they may be obliged to make allowances for you, such as giving you leave of absence for going to the clinic. You may also be entitled to statutory sick pay to cover doctor appointments or time off work.

Therefore, you may want to consider telling your boss about your condition.

Can I travel abroad?

You can travel abroad if you have hepatitis C, but you should speak to your doctor in advance.

You may need to have vaccinations and special arrangements may need to be made to ensure you're able to transport and store your hepatitis C medication safely.

It might also be a good idea to take any documentation, such as details of blood tests or medical records, in case you need medical treatment abroad.

Can I have a baby if my partner or I have hepatitis C?

You can have a baby if you or your partner has hepatitis C, but there's a small risk (around 1 in 20) of hepatitis C passing from mother to baby.

There's also a small risk of the infection spreading to the unaffected partner when having unprotected sex, but this is very unlikely to happen.

Speak to your doctor for advice if you're planning to have a baby and you or your partner has hepatitis C.

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The information on this page has been adapted by NHS Wales from original content supplied by NHS Choices.
Last Updated: 09/09/2015 09:38:34

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