Introduction

Alcohol-related liver disease
Alcohol-related liver disease

Alcohol-related liver disease (ARLD) refers to liver damage caused by excess alcohol intake. There are several stages of severity and a range of associated symptoms.

ARLD doesn't usually cause any symptoms until the liver has been severely damaged. When this happens, symptoms can include:

  • nausea (feeling sick)
  • weight loss
  • loss of appetite
  • yellowing of the eyes and skin (jaundice)
  • swelling in the ankles and abdomen (tummy)
  • confusion or drowsiness
  • vomiting blood or passing blood in your stools

This means that ARLD is frequently diagnosed during tests for other conditions, or at a stage of advanced liver damage.

If you regularly drink alcohol to excess, tell your GP so they can check if your liver is damaged.

Alcohol and the liver

With the exception of the brain, the liver is the most complex organ in the body. It's functions include:

  • filtering toxins from the blood
  • aiding digestion of food
  • regulating blood sugar and cholesterol levels
  • helping to fight infection and disease

The liver is very resilient and is capable of regenerating itself. Each time your liver filters alcohol, some of the liver cells die.

The liver can develop new cells, but prolonged alcohol misuse over many years can reduce your liver’s ability to regenerate. This can result in serious and permanent damage to your liver.

ARLD is very common in the UK, and the number of people with the condition has been increasing over the last few decades because of increasing levels of alcohol misuse.

Stages of ARLD

There are three main stages of alcohol-related liver disease, although there is often an overlap between each stage. The three stages are explained below.

Alcoholic fatty liver disease

Drinking a large amount of alcohol, even for just a few days, can lead to a build-up of fats in the liver. This is called alcoholic fatty liver disease, and is the first stage of ARLD.

Fatty liver disease rarely causes any symptoms, but it's an important warning sign that you're drinking at a harmful level.

Fatty liver disease is reversible. If you stop drinking alcohol for two weeks, your liver should return to normal.

Alcoholic hepatitis

Alcoholic hepatitis (unrelated to infectious hepatitis) is a potentially serious condition that can be caused by alcohol misuse over a longer period. When this develops, it may be the first time a person is aware they're damaging their liver through alcohol.

Less commonly, alcoholic hepatitis can occur if you drink a large amount of alcohol in a short period of time (binge drinking).

The liver damage associated with mild alcoholic hepatitis is usually reversible if you stop drinking permanently.

Severe alcoholic hepatitis, however, is a serious and life-threatening illness. Many people die from the condition each year in the UK and some people only find out they have liver damage when their condition reaches this stage.

Cirrhosis

Cirrhosis is a stage of ARLD where the liver has become significantly scarred. It's generally not reversible, but stopping drinking alcohol immediately can prevent further damage and significantly increase your life expectancy.

Even at this stage, there may not be any obvious symptoms.

A person who has alcohol-related cirrhosis and doesn't stop drinking has less than a 50% chance of living for at least five more years.

How ARLD is treated

There's currently no specific medical treatment for ARLD. The main treatment is to stop drinking, preferably for the rest of your life. This reduces the risk of further damage to your liver and gives your liver the best chance of recovering.

If a person is dependent on alcohol, stopping drinking can be very difficult. However, support, advice and medical treatment may be available through local alcohol support services.

In severe cases, where the liver has stopped functioning and doesn't improve when you stop drinking alcohol, a liver transplant may be required.

You'll only be considered for a liver transplant if you've developed complications of cirrhosis, despite having stopped drinking. All Liver Transplant Units require a person to not drink alcohol while awaiting the transplant and for the rest of their life.

Complications

Death rates linked to ARLD have risen considerably over the last few decades and alcohol is now one of the most common causes of death in the UK, along with smoking and high blood pressure.

Life-threatening complications of ARLD can develop. These include:

  • internal (variceal) bleeding
  • build-up of toxins in the brain (encephalopathy)
  • fluid accumulation in the abdomen (ascites) with associated kidney failure
  • liver cancer

Preventing alcohol-related liver disease

The most effective way to prevent ARLD is to stop drinking alcohol, or stick to the recommended limits.  To keep your risk of alcohol-related harm low, the NHS recommends:

  • not regularly drinking more than 14 units of alcohol a week
  • if you drink as much as 14 units a week, it's best to spread this evenly over three or more days
  • if you're trying to reduce the amount of alcohol you drink, it's a good idea to have several alcohol-free days each week

Regular or frequent drinking means drinking alcohol most weeks. The risk to your health is increased by drinking any amount of alcohol on a regular basis.

A unit of alcohol is equal to about half a pint of normal strength lager or a pub measure (25ml) of spirits. You can use the alcohol units tool to work out whether you're drinking too much.

Even if you've been a heavy drinker for many years, reducing or stopping your alcohol intake will have important short- and long-term benefits for your liver and your overall health.

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Symptoms

In many cases, people with alcohol-related liver disease (ARLD) don't have any noticeable symptoms until their liver is badly damaged.

Early symptoms

If you do experience early symptoms of ARLD, these are often quite vague, such as:

Advanced symptoms

As your liver becomes more severely damaged, you will usually develop more obvious and serious symptoms, such as:

  • yellowing of the skin and whites of the eyes (jaundice)
  • swelling in the legs, ankles and feet (oedema) due to a build up of fluid
  • swelling in your abdomen, due to a build-up of fluid known as ascites
  • a high temperature (fever) and shivering attacks
  • very itchy skin
  • hair loss
  • unusually curved fingertips and nails (clubbed fingers)
  • blotchy red palms
  • significant weight loss
  • weakness and muscle wasting
  • confusion and memory problems, problems sleeping (insomnia) and changes in your personality due to a build-up of toxins in the brain
  • vomiting blood and black, tarry stools due to internal bleeding
  • a tendency to bleed and bruise more easily, such as frequent nosebleeds and bleeding gums
  • increased sensitivity to alcohol and drugs (because the liver cannot process them)

When to seek medical advice

ARLD doesn't often cause symptoms until it's reached an advanced stage. If you misuse alcohol, you may have liver damage, even though you have none of the symptoms above.

Contact your GP for advice if you have a history of regular alcohol misuse.

A good way to assess your history and pattern of drinking is to use a short test known as the CAGE test, which consists of four questions:

  • Have you ever thought you should cut down on your drinking?
  • Have people annoyed you by criticising your drinking?
  • Have you ever felt guilty about your drinking?
  • Have you ever drunk an ‘eye-opener’, which means, have you ever drunk alcohol first thing in the morning to get over a hangover and steady your nerves?

If you answer yes to one or more of the questions above, you may have an alcohol misuse problem and are advised to see your GP.

See your GP as soon as possible if you have symptoms of advanced ARLD.

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Causes

Alcohol-related liver disease (ARLD) is caused by drinking too much alcohol. The more you drink above the recommended limits, the higher your risk of developing ARLD.

There are two ways that alcohol misuse can cause ARLD:

  • drinking a large amount of alcohol in a short amount of time (known as binge drinking) can cause fatty liver disease and, less commonly, alcoholic hepatitis
  • drinking more than the recommended limits of alcohol over many years can cause hepatitis and cirrhosis, the more serious types of ARLD

Evidence suggests that people who regularly drink more than the maximum amounts of alcohol recommended by the NHS are most at risk of developing ARLD.

To keep your risk of alcohol-related harm low, the NHS recommends:

  • not regularly drinking more than 14 units of alcohol a week
  • if you drink as much as 14 units a week, it's best to spread this evenly over three or more days
  • if you're trying to reduce the amount of alcohol you drink, it's a good idea to have several alcohol-free days each week

Regular or frequent drinking means drinking alcohol most weeks. The risk to your health is increased by drinking any amount of alcohol on a regular basis.

Read more about alcohol units and how to calculate them.

Additional factors

As well as drinking excessive amounts of alcohol, there are other factors that can increase your chances of developing ARLD, including:

  • being overweight or obese
  • being female (women appear to be more vulnerable than men to the harmful effects of alcohol)
  • having a pre-existing liver condition, such as hepatitis C
  • genetics - dependence on alcohol and problems processing alcohol often run in families
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Diagnosis

Alcohol-related liver disease (ARLD) is often first suspected when tests for other medical conditions show a damaged liver.

This is because the condition causes few obvious symptoms in the early stages.

If a doctor suspects ARLD, they'll usually arrange a blood test to check how well your liver is working. They may also ask about your alcohol consumption.

It's important to be totally honest about how much and how often you drink alcohol to avoid further unnecessary testing. This could lead to a delay in the treatment you need.

Blood tests

Blood tests used to assess the liver are known as liver function tests. However, liver function tests can be normal at many stages of liver disease.

Blood tests can also detect if you have low levels of certain substances, such as a protein called serum albumin, which is made by the liver. A low level of serum albumin suggests your liver isn't functioning properly.

A blood test may also look for signs of abnormal blood clotting, which can indicate significant liver damage.

Lab Tests Online has more information on liver function tests.

Further testing

If your symptoms or liver function test suggest an advanced form of ARLD – either alcoholic hepatitis or cirrhosis, you may need further tests. These are described below.

Imaging tests

Scans may be needed to produce detailed images of your liver. This may include:

Some scans may also measure the stiffness of the liver, which is a good indication of whether your liver is scarred.

Liver biopsy

During a liver biopsy a fine needle is inserted into your body (usually between your ribs). A small sample of liver cells is taken and sent to a laboratory to be examined under a microscope.

The biopsy is usually carried out under local anaesthetic, either as a day case or with an overnight stay in hospital.

Specialist doctors will examine the liver biopsy tissue under the microscope to determine the degree of scarring in the liver and the cause of the damage.

Endoscopy

An endoscope is a long, thin, flexible tube with a light and a video camera at one end. During an endoscopy, the instrument is passed down your oesophagus (the long tube that carries food from the throat to the stomach) and into your stomach.

Pictures of your oesophagus and stomach are transmitted to an external screen. The doctor will be looking for swollen veins (varices), which are a sign of cirrhosis.

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Treatment

Successful treatment for alcohol-related liver disease (ARLD) often depends on whether someone is willing to stop drinking alcohol and make changes to their lifestyle.

Stopping drinking alcohol

Treatment for ARLD involves stopping drinking alcohol. This is known as abstinence, which can be vital, depending on what stage the condition is at.

If you have fatty liver disease, the damage may be reversed if you abstain from alcohol for at least two weeks. After this point, it's usually safe to start drinking again if you stick to the NHS guidelines on alcohol consumption.

If you have a more serious form of ARLD – alcoholic hepatitis or cirrhosis – life-long abstinence is recommended. This is because stopping drinking is the only way to prevent your liver damage getting worse and potentially stop you dying of liver disease.

Stopping drinking isn't easy, especially as an estimated 70% of people with ARLD have an alcohol dependency problem.

Nevertheless, if you have alcohol-related cirrhosis or alcoholic hepatitis and don't stop drinking, no medical or surgical treatment can prevent liver failure.

Withdrawal symptoms

If you're abstaining from alcohol, you may suffer withdrawal symptoms. These will be at their worst for the first 48 hours, but should start to improve as your body adjusts to being without alcohol. This usually takes three to seven days from the time of your last drink.

Many people initially experience disturbed sleep when abstaining from alcohol, but in most cases their sleep pattern returns to normal within a month.

In some cases, you may be advised to reduce your alcohol intake in a gradual and planned way to help avoid withdrawal problems. You may also be offered a medication called a benzodiazepine and psychological therapy, such as cognitive behavioural therapy (CBT), to help you through the withdrawal process.

Some people need to stay in hospital or a specialist rehabilitation clinic during the initial withdrawal phases, so their progress can be closely monitored.

If you're staying at home, you'll regularly see a nurse or other health professional. You might see them at home, at your GP surgery or at a specialist NHS service.

Preventing relapses

Once you've stopped drinking, you may need further treatment to help ensure you don't start drinking again.

The first treatment usually offered is psychological therapy. This involves seeing a therapist to talk about your thoughts and feelings, and how these affect your behaviour and wellbeing.

If psychological therapy alone isn't effective, you may also need medication to help you abstain from alcohol, such as:

  • acamprosate
  • naltrexone
  • disulfiram

Read our page on treating alcohol misuse for more information on the treatments offered.

Self-help groups

Many people with alcohol dependence find it useful to attend self-help groups to help them stop drinking. One of the most well-known is Alcoholics Anonymous, but there are many other groups that can help.

See Health, Wellbeing & Support search for more information about the help available.

Diet and nutrition

Malnutrition is common in people with ARLD, so it's important to eat a balanced diet to help ensure you get all the nutrients you need.

Avoiding salty foods and not adding salt to foods you eat can reduce your risk of developing swelling in your legs, feet and abdomen (tummy) caused by a build-up of fluid.

The damage to your liver can also mean it's unable to store glycogen – a carbohydrate that provides short-term energy. When this happens, the body uses its own muscle tissue to provide energy between meals, which leads to muscle wasting and weakness. Therefore, you may need extra energy and protein in your diet.

Healthy snacking between meals can top up your calories and protein. It may also be helpful to eat three or four small meals a day, rather than one or two large meals.

Your GP can advise you on a suitable diet or, in some cases, refer you to a dietitian.

In the most serious cases of malnutrition, nutrients may need to be provided through a feeding tube inserted through the nose and into the stomach.

Medication for symptoms

The use of medication to directly treat ARLD is controversial. Many experts have argued there's limited evidence for its effectiveness.

For people with severe alcoholic hepatitis, treatment in hospital may be necessary. Specific treatment with corticosteroidsor pentoxifylline medication may be used to reduce inflammation of the liver in some people with this condition.

Nutritional support (see above) is also an important part of treatment in these cases.

Other medications that have been used to treat liver damage include:

  • anabolic steroids (a more powerful type of steroid medication)
  • ropylthiouracil (a type of medicine originally designed to treat overactive thyroid glands)

However, there's a lack of good evidence that these help and they're no longer used for severe alcoholic hepatitis.

Liver transplants

In the most serious cases of ARLD, the liver loses its ability to function, leading to liver failure. A liver transplantis currently the only way to cure irreversible liver failure.

A liver transplant may be considered if:

  • you develop progressive liver failure, despite not drinking alcohol
  • you're otherwise well enough to survive such an operation
  • you commit to not drinking alcohol for the rest of your life
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Complications

A number of serious complications can develop if you have alcohol-related liver disease (ARLD).

Some of the main complications associated with the condition are described below.

Portal hypertension and varices

Portal hypertension is a common complication of cirrhosis and, less commonly, alcoholic hepatitis. It occurs when the blood pressure inside your liver has risen to a potentially serious level.

When the liver becomes severely scarred, it's harder for blood to move through it. This leads to an increase in the pressure of blood around the intestines.

The blood must also find a new way to return to your heart. It does this by opening up new blood vessels, usually along the lining of your stomach or oesophagus (the long tube that carries food from the throat to the stomach). These new blood vessels are known as varices.

If the blood pressure rises to a certain level, it can become too high for the varices to cope with, causing the walls of the varices to split and bleed.

This can cause long-term bleeding, which can lead to anaemia.

Alternatively, the bleeding can be rapid and massive, causing you to:

  • vomit blood
  • pass stools that are very dark or tar-like

Split varices can be treated by using an endoscope to locate the varices. A tiny band can then be used to seal the base of the varices.

Ascites

A person with portal hypertension may also develop a build-up of fluid in their abdomen (tummy) and around the intestines. This fluid is known as ascites.

Initially, this can be treated with water tablets (diuretics). If the problem progresses, many litres of fluid can build up, which needs to be drained. This is a procedure known as paracentesis and involves a long, thin tube being placed into the fluid through the skin under local anaesthetic.

One of the problems associated with the development of ascites is the risk of infection in the fluid (spontaneous bacterial peritonitis). This is a potentially very serious complication and is linked to an increased risk of kidney failure and death.

Hepatic encephalopathy

One of the most important functions of the liver is to remove toxins from your blood. If the liver is unable to do this due to hepatitis or cirrhosis, the levels of toxins in the blood increase. A high level of toxins in the blood due to liver damage is known as hepatic encephalopathy.

Symptoms of hepatic encephalopathy include:

  • agitation
  • confusion
  • disorientation
  • muscle stiffness
  • muscle tremors
  • difficulty speaking
  • in very serious cases, a coma

Hepatic encephalopathy may require hospital admission. In hospital, body functions are supported and medication is used to remove toxins from the blood.

Liver cancer

Liver damage due to heavy drinking over many years can also increase your risk of developing liver cancer.

Over the past few decades, rates of liver cancer in the UK have risen sharply due to increased levels of alcohol misuse. It's estimated that, every year, 3-5% of people with cirrhosis will develop liver cancer.

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The information on this page has been adapted by NHS Wales from original content supplied by NHS Choices.
Last Updated: 12/01/2016 14:22:17